Acne Research, Ayurveda, Biofeedback, Herbal Medicie, Nutrition, Supplements for Acne

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value='substanceAbuse.asp'>Substance Abuse</option> <option value='temperomania.asp'>Temperomandibular Joint Dis.</option> <option value='tinnitus.asp'>Tinnitus</option> <option value='upperRespiaratory.asp'>Upper Respiratory Infection</option> <option value='vaginitis.asp'>Vaginitis</option> <option value='varicose.asp'>Varicose Veins</option> <option value='vertigo.asp'>Vertigo</option> </select> </form> </td> </tr> </table> </td> <td> </td> </tr>  <tr> <td valign="top" width="149" bgcolor="#ffffff"><img src="../images/spacer.gif" width="149" height="1" border="0" alt=""> </td> <td valign="top" bgcolor="#ffffff">  <table width="100%" cellpadding="0" cellspacing="0" border="0"> <tr> <td nowrap style="padding: 0px 0px 5px 0px;"> <p class="headline"><br> Acne  Scientific Evidence</p> </td> <td width="100%"><img src="../images/spacer.gif" width="1" height="1" border="0" alt=""></td> </tr> <tr> <td bgcolor="95a920"><img src="../images/spacer.gif" width="1" height="1" border="0" alt=""></td> <td width="100%" bgcolor="ffffff" height="1"><img src="../images/spacer.gif" width="1" height="1" border="0" alt=""></td> </tr> <tr> <td bgcolor="ffffff" colspan="2"><img src="../images/spacer.gif" width="1" height="10" border="0" alt=""></td> </tr> </table>  <table width="100%" cellpadding="0" cellspacing="0" border="0"> <tr> <td> <p>Based on scientific evidence the following approaches have shown to be effective. To review the supporting scientific evidence, select a treatment option.</p> <img src='images/square_green.gif' height='7' width='7' border='0' alt=''>  <a target='_self' class=scievBoldGreenLink href='#ayr'>Ayurveda</a><br> <img src='images/square_green.gif' height='7' width='7' border='0' alt=''>  <a target='_self' class=scievBoldGreenLink href='#bio'>Biofeedback</a><br> <img src='images/square_green.gif' height='7' width='7' border='0' alt=''>  <a target='_self' class=scievBoldGreenLink href='#hrb'>Herbal Medicine</a><br> <img src='images/square_green.gif' height='7' width='7' border='0' alt=''>  <a target='_self' class=scievBoldGreenLink href='#nut'>Nutrition/Supplementation</a><br> <p>In order to help interpret the strength of the scientific evidence (the level of proof) provided, descriptions of the different types of studies, reviews and guidelines are available in the <a href="../glossary.asp">glossary</a>. Please click on each term for a discussion of the topic: <a href="../glossary.asp?term=case">Case review</a>, <a href="../glossary.asp?term=consensus">consensus statement</a>, <a href="../glossary.asp?term=control">controlled clinical trial</a>, <a href="../glossary.asp?term=guidelines">guidelines and recommendations</a>, <a href="../glossary.asp?term=literature">literature review</a>, <a href="../glossary.asp?term=meta">meta-analysis</a>, <a href="../glossary.asp?term=multi">multi-center study</a>, <a href="../glossary.asp?term=outcome">outcome study</a>, <a href="../glossary.asp?term=systematic">systematic review</a>. </p> <p><span class='scievModListSubhead'><a name='ayr'></a>Ayurveda</span><br> <span class='scievCitation'>Author(s):</span><br> Paranjpe P, Kulkarni PH<br> <span class='scievCitation'>Institution:</span><br> Acne Clinic, Nanal Hospital, India<br> <span class='scievCitation'>Title:</span><br> Comparative efficacy of four Ayurvedic formulations in the treatment of acne vulgaris: a double-blind randomised placebo-controlled clinical evaluation<br> <span class='scievCitation'>Source:</span><br> Journal of Ethnopharmacology. 49(3)127-32, 1995<br> <span class='scievCitation'>Type of study:</span><br> randomized placebo-controlled clinical trial<br> <span class='scievCitation'>Control/comparison:</span><br> placebo<br> <span class='scievCitation'>Sample characteristics:</span><br> 82 patients with acne<br> <span class='scievCitation'>Type of intervention:</span><br> 4 different Ayurvedic treatments given orally for 6 weeks<br> <span class='scievCitation'>Primary outcome measure(s):</span><br> clinical investigations and lesion count were carried out at 2 week intervals<br> <span class='scievCitation'>Outcome:</span><br> A significant reduction in lesion count was observed in patients receiving Sundar Vati<br> <img height=7 src='images/square_green.gif' width=7 border=0>  <a class=scievBoldOrangeLink href='../tradition_healing/auyrveda_how.asp'>How it Works</a> <img height=1 src='images/spacer.gif' width=15 border=0> <img height=7 src='images/square_green.gif' width=7 border=0>  <a class=scievBoldOrangeLink href='../center/appt.asp'>How to Make an Appointment</a> <img height=1 src='images/spacer.gif' width=15 border=0> <img height=7 src='images/square_green.gif' width=7 border=0>  <a class=scievBoldOrangeLink href='../glossary.asp'>Glossary</a> </p> <p><span class='scievModListSubhead'><a name='bio'></a>Biofeedback</span><br> <span class='scievCitation'>Author(s):</span><br> Hughes H, Brown BW, Lawlis GF, et al.<br> <span class='scievCitation'>Institution:</span><br> Department of Psychology, North Texas State University, Denton, TX<br> <span class='scievCitation'>Title:</span><br> Treatment of acne vulgaris by biofeedback relaxation and cognitive imagery<br> <span class='scievCitation'>Source:</span><br> Journal of Psychosomatic Research. 27(3):185-91, 1983<br> <span class='scievCitation'>Type of study:</span><br> randomized controlled clinical trial<br> <span class='scievCitation'>Control/comparison:</span><br> attention and conventional medical care<br> <span class='scievCitation'>Sample characteristics:</span><br> 30 patients matched on age, sex, pre-treatment and acne severity<br> <span class='scievCitation'>Type of intervention:</span><br> biofeedback-assisted relaxation and cognitive imagery treatment, 12 sessions over six weeks<br> <span class='scievCitation'>Primary outcome measure(s):</span><br> acne severity as measured by Cook, Centner and Michaels photographic standards<br> <span class='scievCitation'>Outcome:</span><br> The treatment resulted in a significant reduction of acne severity compared to the attention and medical care. Treatment group patients who continued home practice until follow-up maintained their gains, whereas those who discontinued failed to maintain gains.<br> <img height=7 src='images/square_green.gif' width=7 border=0>  <a class=scievBoldOrangeLink href='../complement/bio_how.asp'>How it Works</a> <img height=1 src='images/spacer.gif' width=15 border=0> <img height=7 src='images/square_green.gif' width=7 border=0>  <a class=scievBoldOrangeLink href='../center/appt.asp'>How to Make an Appointment</a> <img height=1 src='images/spacer.gif' width=15 border=0> <img height=7 src='images/square_green.gif' width=7 border=0>  <a class=scievBoldOrangeLink href='../glossary.asp'>Glossary</a> </p> <p><span class='scievModListSubhead'><a name='hrb'></a>Herbal Medicine</span><br> <span class='scievCitation'>Author(s):</span><br> Bassett IB, Pannowitz DL, Barnetson RS<br> <span class='scievCitation'>Institution:</span><br> Department of Dermatology, Royal Prince Alfred Hospital, Camperdown, NSW<br> <span class='scievCitation'>Title:</span><br> A comparative study of tea-tree oil versus benzoylperoxide in the treatment of acne<br> <span class='scievCitation'>Source:</span><br> Medical Journal of Australia. 153(8):455-8, 1990<br> <span class='scievCitation'>Type of study:</span><br> randomized controlled clinical trial.<br> <span class='scievCitation'>Control/comparison:</span><br> efficacy and skin tolerance of 5% benzoyl peroxide<br> <span class='scievCitation'>Sample characteristics:</span><br> 124 patients with mild to moderate acne<br> <span class='scievCitation'>Type of intervention:</span><br> use of 5 tea-tree oil gel on skin<br> <span class='scievCitation'>Primary outcome measure(s):</span><br> number of inflamed and non-inflamed lesions (open and closed comedones)<br> <span class='scievCitation'>Outcome:</span><br> The results of this study showed that both 5% tea-tree oil and 5% benzoyl peroxide had significant effect in ameliorating the patients’ acne by reducing the number of inflamed and non-inflamed lesions (open and closed comedones). Although the onset of action in the case of the tea-tree oil was slower, fewer side effects were experienced by the patients treated with tea-tree oil.<br> </p> <p><span class='scievCitation'>Author(s):</span><br> Higaki S., Nakamura M., Morohashi M, et al.<br> <span class='scievCitation'>Institution:</span><br> Dr. S. Higaki, Department of Dermatology, Faculty of Medicine, Toyama Medical/Pharmaceutical University , 2630 Sugitani, Toyama-she 930-01, Japan<br> <span class='scievCitation'>Title:</span><br> Activity of eleven Kampo formulations and eight Kampo crude drugs against Propionibacterium acnes isolated from acne patients: Retrospective evaluation in 1990 and 1995<br> <span class='scievCitation'>Source:</span><br> Journal of Dermatology. 23: 871-875, 1996<br> <span class='scievCitation'>Type of study:</span><br> in vitro lab study<br> <span class='scievCitation'>Control/comparison:</span><br> comparing the minimum inhibitory concentrations (MIC) in 1990 and 1995 of 11 Kampo formulations and 8 Kampo crude drugs against Probionibacterium acnes isolated from acne<br> <span class='scievCitation'>Sample characteristics:</span><br> Propionibacterium acne strains<br> <span class='scievCitation'>Type of intervention:</span><br> 11 Kampo formulations and 8 Kampo crude drugs<br> <span class='scievCitation'>Primary outcome measure(s):</span><br> Primary outcome measure(s): examining the minimum inhibitory concentrations (MIC) in 1990 and 1995 of 11 Kampo formulations and 8 Kampo crude drugs against Probionibacterium acnes isolated from acne<br> <span class='scievCitation'>Outcome:</span><br> Probionibacterium acne strains were most sensitive to Oren-gedoku-to (OGT) among these Kampo formulations. Coptidis Rhizoma (CR) and Phellodendri Cortex (PC) inhibited the growth of Probionibacterium acnes significantly among the eight Kampo crude drugs examined. No significant increases in MIC of Kampo formulations and Kampo crude drugs to Probionibacterium acne were observed. The speculation was made that Kampo crude drugs such as CR and PC were better than minocycline or erythromycin from the point of a progressive increase in MIC to Probionibacterium acne. CR and PC, which were each an ingredient of OGT, might contain some components with strong antibacterial activity to Probionibacterium acne.<br> <img height=7 src='images/square_green.gif' width=7 border=0>  <a class=scievBoldOrangeLink href='../complement/herbal_how.asp'>How it Works</a> <img height=1 src='images/spacer.gif' width=15 border=0> <img height=7 src='images/square_green.gif' width=7 border=0>  <a class=scievBoldOrangeLink href='../center/appt.asp'>How to Make an Appointment</a> <img height=1 src='images/spacer.gif' width=15 border=0> <img height=7 src='images/square_green.gif' width=7 border=0>  <a class=scievBoldOrangeLink href='../glossary.asp'>Glossary</a> </p> <p><span class='scievModListSubhead'><a name='nut'></a>Nutrition/Supplementation</span><br> <span class='scievCitation'>Author(s):</span><br> Vahlquist A, Michaelsson G, Juhlin L<br> <span class='scievCitation'>Institution:</span><br> Department of Dermatology, University Hospital, Uppsala, Sweden<br> <span class='scievCitation'>Title:</span><br> Acne treatment with oral zinc and vitamin A: effects on the serum levels of zinc and retinol binding protein (RBP)<br> <span class='scievCitation'>Source:</span><br> Acta Dermato-Venereologica. 59(5):437-42, 1978<br> <span class='scievCitation'>Type of study:</span><br> randomized controlled clinical trial<br> <span class='scievCitation'>Control/comparison:</span><br> vitamin A and placebo<br> <span class='scievCitation'>Sample characteristics:</span><br> 75 patients with acne, 53 males and 22 females, between the ages of 15 and 25 years old<br> <span class='scievCitation'>Type of intervention:</span><br> oral treatment with zinc sulphate effervescent tablets<br> <span class='scievCitation'>Primary outcome measure(s):</span><br> serum zinc level after 2 and 4 weeks and 3 months, clinical improvement of acne<br> <span class='scievCitation'>Outcome:</span><br> There was an increase in the mean serum zinc level in the zinc-treated patients after 2 weeks, the time when the first clinical improvement occurred. After 4 weeks the zinc level had increased by about 30% and no further significant increase was observed during 3 months of treatment. In the 33 healthy subjects there was an increase of 14% after 4 weeks of zinc therapy. Vitamin A and placebo induced no significant changes in the serum zinc status.<br> </p> <p><span class='scievCitation'>Author(s):</span><br> Vahlquist A, Michaelsson G, Juhlin L<br> <span class='scievCitation'>Institution:</span><br> Department of Dermatology and Clinical Research, Uppsala University Hospital, Uppsala, Sweden<br> <span class='scievCitation'>Title:</span><br> Effects of oral zinc and vitamin A in acne<br> <span class='scievCitation'>Source:</span><br> Archives of Dermatology. 113(1):31-6, 1977<br> <span class='scievCitation'>Type of study:</span><br> controlled clinical trial<br> <span class='scievCitation'>Control/comparison:</span><br> vitamin A and placebo<br> <span class='scievCitation'>Sample characteristics:</span><br> 64 patients, 38 male and 26 female, between 13 and 25 years of age with grades 2 to 4 acne.<br> <span class='scievCitation'>Type of intervention:</span><br> 135 mg oral zinc sulfate daily alone and in combination with 300,000 IU vitamin A daily on acne lesions<br> <span class='scievCitation'>Primary outcome measure(s):</span><br> change in number of comedones, papules, pustules, and infiltrates were counted at each visit<br> <span class='scievCitation'>Outcome:</span><br> After 4 weeks there was a significant decrease in the number of papules, pustules, and infiltrates in the zinc-treated groups. The effects of zinc plus vitamin A was not better than zinc alone. After 12 weeks of treatment, the mean acne score had decreased from 100% to 15%. The mechanism for the effect of zinc therapy in acne is not presently known.<br> </p> <p><span class='scievCitation'>Author(s):</span><br> Gandola M, Argeniano G, Barba C, et al.<br> <span class='scievCitation'>Institution:</span><br>  <br> <span class='scievCitation'>Title:</span><br> Topical vitamin A acid in the treatment of acne vulgaris (a controlled multicenter trial)<br> <span class='scievCitation'>Source:</span><br> Archives of Dermatological Research - Archiv fur Dermatologische Forschung. 255(2):129-38, 1976<br> <span class='scievCitation'>Type of study:</span><br> controlled multi-center trial<br> <span class='scievCitation'>Control/comparison:</span><br> salicylic acid and placebo<br> <span class='scievCitation'>Sample characteristics:</span><br> 211 acne patients in comparable groups<br> <span class='scievCitation'>Type of intervention:</span><br> application of topical retinoid acid against sulfur-resorcinol--salicylic acid and placebo<br> <span class='scievCitation'>Primary outcome measure(s):</span><br> uniform evaluation criteria<br> <span class='scievCitation'>Outcome:</span><br> After 8 weeks' treatment in comparable groups of patients, retinoic acid proved to be superior to the standard and to the placebo. The difference was statistically significant. Side effects were present in a number of patients treated with the active substances and with the placebo (mainly erythema), but rarely was the treatment discontinued.<br> <img height=7 src='images/square_green.gif' width=7 border=0>  <a class=scievBoldOrangeLink href='../complement/nutrition_how.asp'>How it Works</a> <img height=1 src='images/spacer.gif' width=15 border=0> <img height=7 src='images/square_green.gif' width=7 border=0>  <a class=scievBoldOrangeLink href='../center/appt.asp'>How to Make an Appointment</a> <img height=1 src='images/spacer.gif' width=15 border=0> <img height=7 src='images/square_green.gif' width=7 border=0>  <a class=scievBoldOrangeLink href='../glossary.asp'>Glossary</a> </p> <p> </p> </td> </tr>  <tr> <br /><a class='disclaimer' href='../disclaimer.asp'>Disclaimer</a> </tr> <tr> <td class="timestamp"><br> <br>Content last modified on Nov 5, 2002</td> </tr> </table> </td> <td valign="top" bgcolor="#ffffff"><img src="../images/bg_curve.gif" width="60" height="300" align="right" border="0" vspace="0" hspace="0"></td> </tr> <tr> <td bgcolor="#ffffff"><img src="../images/spacer.gif" width="1" height="1" border="0" alt=""></td> <td bgcolor="#ffffff"><img src="../images/spacer.gif" width="1" height="1" border="0" alt=""></td> <td bgcolor="#ffffff"><img src="../images/spacer.gif" width="1" height="200" border="0" alt=""></td> </tr>  <tr> <td width="149" bgcolor="ffffff"> </td> <td colspan="2" bgcolor="ffffff"> <p> </p> <p class="copyright">©2002 Center for Health and Healing</p> </td> </tr> </table> </body> </html>